Lower sulfurtransferase detoxification rates of cyanide in konzo—A tropical spastic paralysis linked to cassava cyanogenic poisoning
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چکیده
منابع مشابه
Detoxification Effect of Fermentation on Cyanide Content of Cassava Tuber
Cassava is a staple food for approximately 800 million people in tropical countries. The tuber which comprises mainly starch also contains high concentration cyanogenic glycosides which give rise to the hydrocyanic acid by enzymatic hydrolysis. The purpose this research therefore is to investigate the detoxification potential of fermentation, on the toxic (cyanide) content of cassava tuber. The...
متن کاملUptake of wetting method in Africa to reduce cyanide poisoning and konzo from cassava.
Cassava contains cyanogenic glucosides which are hydrolysed by an enzyme linamarase to produce cyanohydrins which breakdown to toxic cyanide. Cyanide ingestion from bitter cassava can cause cyanide poisoning sometimes leading to death and also konzo, an irreversible paralysis of the legs which occurs mainly in children and young women. In 2005 we developed a simple wetting method that reduces t...
متن کاملOccupational and dietary exposures of humans to cyanide poisoning from large-scale cassava processing and ingestion of cassava foods.
The biochemical and toxicological effects of occupational and dietary exposure of humans to cyanide poisoning from large-scale cassava processing and ingestion of cassava foods were investigated using spectrophotometric and enzymatic methods. Analysis of urinary and serum thiocyanate (cyanide metabolite) from workers in cassava processing industries, who were 'frequent' [those who eat cassava f...
متن کاملChronic poisoning by hydrogen cyanide in cassava and its prevention in Africa and Latin America.
Africa produces more than 30 million tons of cassava on about 5 million hectares (6 tons per hectare). Approximately 80% of the root production and 70% of the harvested area are from Western Africa. Recent reports suggest that the ingestion of poorly processed cassava roots is associated with the incidence of an ataxic neuropathy (konzo) in African countries. When cassava-based diets are not su...
متن کاملHydrogen Cyanide Sensitivity in Bacterial Pathogens of Cyanogenic and Non-Cyanogenic Plants
RUST, L. A., W. E. FRY, and S. V. BEER. 1980. Hydrogen cyanide sensitivity in bacterial pathogens of cyanogenic and non-cyanogenic plants. Phytopathology 70:1005-1008. The cyanide sensitivity of bacterial pathogens of cyanogenic and nongenerally were more sensitive to HCN than were the xanthomonads tested. cyanogenic plants was determined by observing the effects of HCN on their Among xanthomon...
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ژورنال
عنوان ژورنال: NeuroToxicology
سال: 2017
ISSN: 0161-813X
DOI: 10.1016/j.neuro.2016.05.016